The companies are merging and acquiring in order to grow the market for anti-body linked T receptor therapy

 Anti-body coupled T receptor (ACTR) therapy is a type of cancer immunotherapy in which the body's own immune system is employed to attack malignant cells. Antibody-linked T receptor therapy takes T cells from the patient's body, modifies them to express a specific T cell receptor, multiplies them in the lab, and then administers them along with antibodies that target them. The advantage of this method is that these T cells selectively attack antigens associated with malignant cells, rather than normal antigens found in the bloodstream. This is conceivable because ACTR T cells are combined with tumor-specific monoclonal antibodies. Because ACTR therapy can be employed in a variety of cancer treatments, it is cost-effective. Adjusting the amount of targeted antibody required for ACTR T cell activation can also provide a larger therapeutic benefit with fewer side effects



The companies are merging and acquiring in order to grow the market for anti-body linked T receptor therapy.

Unum Therapeutics is the sole company working on anti-body linked T receptor treatment at the moment. It has a number of products in development, which differ depending on the method utilized to produce the receptor in the patient's T cell, such as mRNA or viral vector. For coupling, different monoclonal antibodies such as rituximab and trastuzumab might be used in conjunction. Rituximab combined t receptor treatment was found to provide the expected therapeutic results in a phase one clinical investigation. In 2015, Seattle Genetics, Inc. and Unum Therapeutics, Inc. formed a strategic partnership and license agreement to develop and market innovative antibody-coupled T-cell receptor (ACTR) cancer medicines. This agreement will allow researchers to test different combinations of tumor-specific monoclonal antibodies with T receptors and tailor treatments to individual patients' requirements.

Rising incidence of cancer and new products to be launched in future to drive the market for anti-body coupled T receptor therapy market.

Cancer is one of the most common non-communicable diseases and the second largest cause of death worldwide, according to the World Health Organization (WHO). According to the International Agency for Research on Cancer (IARC), there were 14.1 million new cases, 8.8 million deaths, and 32.6 million cancer patients worldwide in 2012. According to a 2017 report by the Leukemia and Lymphoma Society, the United States alone is predicted to have an annual lymphoma prevalence of 8,16,834 and 80,500 new cases of lymphoma. As a result, the Anti-body Coupled T Receptor Therapy Market would be propelled by such a large number of cancer patients.

Other adoptive T cell transfer technologies, such as CAR-T cell therapy, take a different strategy than ACTR therapy. As mentioned in their respective product literature and other studies, CAR-T therapy products such as Kymriah (Novartis AG) and Yescarta (Gilead Lifescience, Inc.) have adverse effects such as cytokine release syndrome and neurological damage. Because ACTR therapy is so specialized in its function, it has no negative side effects. In the future, this advantage will drive the anti-body linked T receptor therapy market. CAR-T therapy is also used in particular cancers such as non-Hodgkin lymphoma, acute lymphoblastic leukemia, and multiple myeloma, whilst ACTR therapy could be used in solid tumors like breast cancer and glioblastoma.

The price of a product might be a crucial consideration. Kymriah, a CAR-T treatment, is estimated to cost around $4,75,000 per patient. Because CAR-T therapy is so expensive, it's reasonable to think that anti-body linked T receptor therapy will be similarly expensive because it works in the same immuno-oncology segment, which could limit the Anti-body Coupled T Receptor Therapy Market potential growth.

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